TBC1D25

Across TCGA patient cohorts, TBC1D25 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D25-associated genes across cancer lineages are FOXO3a_pS318_S321, GATA6, and MEK1. Each is linked with TBC1D25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D25-to-partner and partner-to-TBC1D25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TBC1D25-low versus TBC1D25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D25→partner) and Y-score (partner→TBC1D25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.093	-1.706	.011	.003	3	2
UCEC	GATA6 →	-0.112	-1.685	.016	.039	3	2
UCEC	MEK1 →	+0.302	+1.432	.005	.005	3	2
UCEC	p53 →	-0.275	-2.000	.015	.029	3	2
UCEC	p62 Lck ligand →	+0.260	+1.450	.006	.014	3	2
UCEC	Annexin-1 →	+0.553	+2.189	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

FOXO3a_pS318_S321 by TBC1D25 expression — UCEC

Explore this box plot interactively →