TBC1D25

Across TCGA cell cohorts, TBC1D25 mutation is significantly associated with the drug of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D25-associated genes across cancer lineages are 630600, AGI-5198, and AKT inhibitor VIII. Each is linked with TBC1D25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D25-to-partner and partner-to-TBC1D25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 630600 grouped by TBC1D25-low versus TBC1D25-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D25→partner) and Y-score (partner→TBC1D25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	630600 →	+0.603	+2.871	.041	.021	3	1
LARGE_INTESTINE	AGI-5198 →	+0.284	+2.649	.046	.046	3	1
LARGE_INTESTINE	AKT inhibitor VIII →	+0.532	+2.874	.029	.021	3	1
LARGE_INTESTINE	Masitinib →	+0.469	+2.874	.021	.021	3	1
LARGE_INTESTINE	Fedratinib →	+0.512	+2.874	.039	.021	3	1
LARGE_INTESTINE	BMS-536924 →	+0.676	+2.649	.017	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

630600 by TBC1D25 expression — LARGE_INTESTINE

Explore this box plot interactively →