TBC1D23

Across TCGA pan-cancer cohorts, TBC1D23 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TBC1D23 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TBC1D23 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D23 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

GBM, COAD, and UCEC are the cancer types where TBC1D23 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.244	0.507	<.001	22	view →
COAD	DFS	Median	II,III,IV	1.000	0.889	.033	12	view →
UCEC	DFS	Tertile	All	0.971	0.758	.005	12	view →
PDAC	DFS	Tertile	III,IV	0.194	0.577	.012	6	view →
LUAD	OS	Median	II,III,IV	0.968	0.894	.044	1	view →
LSCC	OS	Median	All	0.800	1.000	.044	1	view →
HNSC	DFS	Tertile	III,IV	0.877	0.671	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TBC1D23–GBM (DFS)

Open the GBM breakdown →