TBC1D23

Across TCGA patient cohorts, TBC1D23 mutation is significantly associated with the RNA expression of many other genes, with 1,942 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D23-associated genes across cancer lineages are RNU6-781P, RNA5SP366, and NDUFAF5. Each is linked with TBC1D23 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D23-to-partner and partner-to-TBC1D23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-781P grouped by TBC1D23-low versus TBC1D23-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D23→partner) and Y-score (partner→TBC1D23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-781P →	+0.543	+3.838	<.001	.006	3	3
BLCA	RNA5SP366 →	+0.244	+5.033	.003	.003	3	2
UCEC	NDUFAF5 →	+0.386	+1.852	<.001	.001	3	2
UCEC	MLX →	+0.488	+2.545	<.001	<.001	3	2
UCEC	EXOSC8 →	+0.425	+1.545	<.001	.005	3	2
UCEC	CCDC59 →	+0.340	+2.439	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,942 associations by consensus.

RNU6-781P by TBC1D23 expression — SKCM

Explore this box plot interactively →