TBC1D23

Across TCGA patient cohorts, TBC1D23 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D23-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and eIF4G. Each is linked with TBC1D23 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D23-to-partner and partner-to-TBC1D23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TBC1D23-low versus TBC1D23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D23→partner) and Y-score (partner→TBC1D23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.105	-2.780	.003	.003	3	1
UCEC	eIF4E →	+0.217	+2.392	.003	<.001	3	1
UCEC	eIF4G →	+0.268	+2.115	.014	.016	3	1
UCEC	A-Raf_pS299 →	-0.116	-1.700	.005	.042	3	1
UCEC	ERK2 →	+0.177	+2.415	.009	.003	3	1
UCEC	INPP4B →	-0.354	-3.807	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

14-3-3_beta by TBC1D23 expression — UCEC

Explore this box plot interactively →