TBC1D22A

Across TCGA pan-cancer cohorts, TBC1D22A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TBC1D22A data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TBC1D22A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D22A expression acts as an unfavorable survival marker.

LSCC, HNSC, and CCRCC are the cancer types where TBC1D22A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.492	0.976	<.001	27	view →
HNSC	OS	Tertile	III,IV	0.484	0.857	<.001	16	view →
CCRCC	DFS	Tertile	III,IV	0.427	0.717	.035	7	view →
PDAC	DFS	Median	III,IV	0.425	0.887	.009	7	view →
LUAD	OS	Tertile	All	0.747	0.901	.020	5	view →
GBM	DFS	Median	All	0.623	0.810	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TBC1D22A–LSCC (DFS)

Open the LSCC breakdown →