TBC1D21

Across TCGA patient cohorts, TBC1D21 mutation is significantly associated with the RNA expression of many other genes, with 427 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D21-associated genes across cancer lineages are RN7SL271P, RNU6-565P, and RNA5SP505. Each is linked with TBC1D21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D21-to-partner and partner-to-TBC1D21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL271P grouped by TBC1D21-low versus TBC1D21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D21→partner) and Y-score (partner→TBC1D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL271P →	+0.099	+4.488	<.001	.003	3	2
LUAD	RNU6-565P →	+0.458	+4.481	<.001	.009	3	2
ESCA	RNA5SP505 →	+0.453	+5.450	<.001	.004	3	2
LUSC	SNORD116-9 →	+0.406	+5.548	<.001	.004	3	2
UCEC	MEX3D →	+0.709	+3.480	.001	.002	3	2
UCEC	SGTA →	+0.461	+3.649	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 427 associations by consensus.

RN7SL271P by TBC1D21 expression — SKCM

Explore this box plot interactively →