TBC1D21

Across TCGA patient cohorts, TBC1D21 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D21-associated genes across cancer lineages are EGFR_pY1068, MEK1, and p62 Lck ligand. Each is linked with TBC1D21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D21-to-partner and partner-to-TBC1D21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TBC1D21-low versus TBC1D21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D21→partner) and Y-score (partner→TBC1D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-2.700	.025	.006	3	1
UCEC	MEK1 →	+0.407	+2.000	.013	.032	3	1
UCEC	p62 Lck ligand →	+0.604	+3.469	<.001	.002	3	1
UCEC	PCNA →	+0.206	+3.169	.034	.019	3	1
UCEC	PDCD4 →	-0.681	-3.459	.001	.005	3	1
UCEC	CD49b →	-0.264	-2.980	.039	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by TBC1D21 expression — UCEC

Explore this box plot interactively →