TBC1D21

Across TCGA cell cohorts, TBC1D21 RNA expression is significantly associated with the mutation status of many other genes, with 393 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D21-associated genes across cancer lineages are ACVR1B, UPK3BL1, and GOT1. Each is linked with TBC1D21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D21-to-partner and partner-to-TBC1D21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVR1B grouped by TBC1D21-low versus TBC1D21-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D21→partner) and Y-score (partner→TBC1D21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACVR1B →	+5.977	+0.023	.001	<.001	3	2
LARGE_INTESTINE	UPK3BL1 →	+3.700	+0.008	.009	<.001	3	2
LARGE_INTESTINE	GOT1 →	+4.437	+0.012	.004	<.001	3	2
CNS	AK7 →	+5.357	+0.017	.001	<.001	3	2
STOMACH	IKBIP →	+4.129	+0.076	.007	<.001	3	2
STOMACH	ANKRD18A →	+4.129	+0.076	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 393 associations by consensus.

ACVR1B by TBC1D21 expression — SOFT_TISSUE

Explore this box plot interactively →