TBC1D20

Across TCGA cell cohorts, TBC1D20 mutation is significantly associated with the mutation status of many other genes, with 3,482 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D20-associated genes across cancer lineages are DENND4B, VCAN, and DOCK5. Each is linked with TBC1D20 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBC1D20-to-partner and partner-to-TBC1D20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DENND4B grouped by TBC1D20-low versus TBC1D20-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D20→partner) and Y-score (partner→TBC1D20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DENND4B →	+3.020	+4.545	.004	.004	1	4
OESOPHAGUS	VCAN →	+3.672	+4.307	.004	.004	1	3
OESOPHAGUS	DOCK5 →	+3.087	+4.000	.008	.008	1	3
OESOPHAGUS	OBSL1 →	+3.087	+4.000	.008	.008	1	3
LARGE_INTESTINE	BTAF1 →	+2.289	+3.182	.008	.008	1	3
BLOOD_Leukemia	ZNFX1 →	+3.672	+5.083	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,482 associations by consensus.

DENND4B by TBC1D20 expression — BLOOD_Leukemia

Explore this box plot interactively →