TBC1D2

Across TCGA pan-cancer cohorts, TBC1D2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TBC1D2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TBC1D2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where TBC1D2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.263	0.552	<.001	44	view →
CCRCC	DFS	Quartile	III,IV	0.264	0.696	<.001	18	view →
UCEC	OS	Median	All	1.000	0.898	.004	14	view →
HNSC	DFS	Median	II,III,IV	0.860	0.690	.021	6	view →
LUAD	OS	Median	All	0.757	0.913	.002	5	view →
LSCC	OS	Tertile	All	0.766	0.944	.010	3	view →
GBM	OS	Quartile	All	0.762	0.967	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TBC1D2–PDAC (DFS)

Open the PDAC breakdown →