TBC1D2

Across TCGA patient cohorts, TBC1D2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D2-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and Chk1. Each is linked with TBC1D2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D2-to-partner and partner-to-TBC1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TBC1D2-low versus TBC1D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D2→partner) and Y-score (partner→TBC1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.133	-1.794	.008	.024	3	3
UCEC	Caspase-7-cleavedD198 →	+0.463	+1.926	.021	.008	3	3
COAD	Chk1 →	+0.417	+2.815	<.001	.036	3	2
UCEC	eIF4E →	+0.150	+1.887	.037	.029	3	2
UCEC	Ku80 →	+0.236	+1.527	.003	.009	3	2
UCEC	STAT3_pY705 →	-0.379	-1.807	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

mTOR_pS2448 by TBC1D2 expression — UCEC

Explore this box plot interactively →