TBC1D2

Across TCGA cell cohorts, TBC1D2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,566 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TBC1D2-associated GO terms across cancer lineages are Cell-substrate junction assembly, Regulation of cell-substrate adhesion, and Membrane raft assembly. Each is linked with TBC1D2 in more than 14 cancer types. Because this analysis shows association rather than direction, both TBC1D2-to-partner and partner-to-TBC1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction assembly grouped by TBC1D2-low versus TBC1D2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D2→partner) and Y-score (partner→TBC1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cell-substrate junction assembly →	+0.123	+1.203	<.001	<.001	3	15
BONE	Regulation of cell-substrate adhesion →	+0.125	+1.932	<.001	<.001	3	14
LIVER	Membrane raft assembly →	+0.189	+1.721	<.001	.002	3	14
BONE	Positive regulation of plasma membrane repair →	+0.278	+2.408	<.001	<.001	3	14
OESOPHAGUS	Regulation of cytokine-mediated signaling pathway →	+0.079	+1.824	<.001	<.001	3	14
SOFT_TISSUE	Membrane raft organization →	+0.148	+1.371	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,566 associations by consensus.

Cell-substrate junction assembly by TBC1D2 expression — BREAST

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