TBC1D2

Across TCGA cell cohorts, TBC1D2 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D2-associated genes across cancer lineages are OR10C1, GFRA4, and MYF5. Each is linked with TBC1D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D2-to-partner and partner-to-TBC1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10C1 grouped by TBC1D2-low versus TBC1D2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D2→partner) and Y-score (partner→TBC1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10C1 →	+0.025	+3.681	<.001	.009	3	2
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	1
OVARY	MYF5 →	+0.011	+3.807	<.001	.009	3	1
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	OR10A2 →	+0.027	+3.724	.004	.004	3	1
OVARY	C8orf74 →	+0.104	+3.263	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

OR10C1 by TBC1D2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →