TBC1D17

Across TCGA patient cohorts, TBC1D17 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D17-associated genes across cancer lineages are EGFR_pY1068, EGFR, and JNK_pT183_Y185. Each is linked with TBC1D17 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D17-to-partner and partner-to-TBC1D17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TBC1D17-low versus TBC1D17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D17→partner) and Y-score (partner→TBC1D17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.264	-3.169	.023	.019	3	1
UCEC	EGFR →	-0.235	-3.000	.001	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.242	-2.321	.002	.034	3	1
UCEC	MAPK_pT202_Y204 →	-0.520	-2.321	.017	.034	3	1
UCEC	MEK1 →	+0.471	+2.321	.005	.034	3	1
UCEC	mTOR_pS2448 →	-0.187	-3.302	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by TBC1D17 expression — UCEC

Explore this box plot interactively →