TBC1D17

Across TCGA cell cohorts, TBC1D17 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TBC1D17-associated genes across cancer lineages are GJD2, IL31, and IRX4. Each is linked with TBC1D17 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D17-to-partner and partner-to-TBC1D17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by TBC1D17-low versus TBC1D17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D17→partner) and Y-score (partner→TBC1D17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	IL31 →	+0.023	+3.103	<.001	.004	3	1
OVARY	IRX4 →	+0.395	+3.639	<.001	.002	3	1
OVARY	EVX2 →	+0.025	+3.295	.004	.009	3	1
OVARY	OR52N2 →	+0.098	+2.974	<.001	.006	3	1
OVARY	NPBWR1 →	+0.778	+3.237	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GJD2 by TBC1D17 expression — LARGE_INTESTINE

Explore this box plot interactively →