TBC1D16

Across TCGA pan-cancer cohorts, TBC1D16 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TBC1D16 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TBC1D16 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TBC1D16 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, GBM, and LSCC are the cancer types where TBC1D16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	1.000	0.446	.030	8	view →
GBM	OS	Tertile	All	0.319	0.588	.005	6	view →
LSCC	DFS	Quartile	All	0.207	1.000	.006	6	view →
CCRCC	OS	Quartile	All	0.526	1.000	.004	5	view →
HNSC	DFS	Quartile	All	0.662	0.965	.030	4	view →
LUAD	OS	Median	All	0.884	0.706	.018	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TBC1D16–UCEC (DFS)

Open the UCEC breakdown →