TBC1D16

Across TCGA patient cohorts, TBC1D16 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D16-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and TFRC. Each is linked with TBC1D16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D16-to-partner and partner-to-TBC1D16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TBC1D16-low versus TBC1D16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D16→partner) and Y-score (partner→TBC1D16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.298	-2.247	.001	.001	3	2
UCEC	eIF4E →	+0.168	+2.472	.030	.010	3	2
UCEC	TFRC →	+0.545	+3.459	.005	.005	3	2
UCEC	VHL →	-0.923	-2.321	<.001	.005	3	2
UCEC	ATM →	-0.678	-2.893	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.578	+3.459	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by TBC1D16 expression — UCEC

Explore this box plot interactively →