TBC1D16

Across TCGA cell cohorts, TBC1D16 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D16-associated genes across cancer lineages are KLHL40, GHRH, and GFRA4. Each is linked with TBC1D16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D16-to-partner and partner-to-TBC1D16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by TBC1D16-low versus TBC1D16-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D16→partner) and Y-score (partner→TBC1D16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KLHL40 →	+0.005	+3.688	<.001	.002	3	2
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
BLOOD_Leukemia	GFRA4 →	+0.308	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TSHB →	+0.128	+4.276	.003	.007	3	1
BLOOD_Leukemia	OR10K2 →	+0.060	+4.705	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

KLHL40 by TBC1D16 expression — SKIN

Explore this box plot interactively →