TBC1D14

Across TCGA pan-cancer cohorts, TBC1D14 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TBC1D14 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TBC1D14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D14 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

UCEC, LSCC, and PDAC are the cancer types where TBC1D14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.738	1.000	<.001	26	view →
LSCC	DFS	Tertile	All	0.187	0.871	<.001	14	view →
PDAC	OS	Median	II,III,IV	0.652	0.450	.018	8	view →
HNSC	OS	Median	All	0.449	1.000	.023	7	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	7	view →
LUAD	OS	Tertile	II,III,IV	0.848	0.388	.047	2	view →
GBM	DFS	Quartile	All	0.619	0.880	.011	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TBC1D14–UCEC (DFS)

Open the UCEC breakdown →