TBC1D12

Across TCGA patient cohorts, TBC1D12 mutation is significantly associated with the RNA expression of many other genes, with 3,348 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D12-associated genes across cancer lineages are DSTNP5, OR9L1P, and MIR609. Each is linked with TBC1D12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D12-to-partner and partner-to-TBC1D12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSTNP5 grouped by TBC1D12-low versus TBC1D12-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D12→partner) and Y-score (partner→TBC1D12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	DSTNP5 →	+0.074	+4.306	<.001	<.001	3	2
THCA	OR9L1P →	+0.023	+5.141	<.001	.002	3	2
GBM	MIR609 →	+1.062	+4.969	<.001	.009	3	2
READ	MRPS5P3 →	+0.377	+4.533	<.001	.004	3	2
READ	CCNT2P1 →	+0.050	+5.257	<.001	.002	3	2
COAD	HMGB1P32 →	+0.169	+5.003	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,348 associations by consensus.

DSTNP5 by TBC1D12 expression — THCA

Explore this box plot interactively →