TBC1D12

Across TCGA patient cohorts, TBC1D12 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible TBC1D12-associated genes across cancer lineages are XBP1, eEF2, and p90 RSK_pT359_S363. Each is linked with TBC1D12 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D12-to-partner and partner-to-TBC1D12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by TBC1D12-low versus TBC1D12-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D12→partner) and Y-score (partner→TBC1D12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	XBP1 →	+0.092	+1.299	.039	.020	3	3
BLCA	eEF2 →	+0.135	+1.017	.015	.045	3	2
BLCA	p90 RSK_pT359_S363 →	-0.154	-1.930	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.430	-2.115	<.001	.016	3	2
BLCA	C-Raf_pS338 →	-0.062	-1.514	.039	.010	3	2
UCEC	Ku80 →	+0.238	+3.183	.012	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

XBP1 by TBC1D12 expression — BLCA

Explore this box plot interactively →