TBC1D12

Across TCGA cell cohorts, TBC1D12 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D12-associated genes across cancer lineages are SH3GL2, PCCB, and SERAC1. Each is linked with TBC1D12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D12-to-partner and partner-to-TBC1D12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by TBC1D12-low versus TBC1D12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D12→partner) and Y-score (partner→TBC1D12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.016	+3.252	.008	.009	3	1
LARGE_INTESTINE	PCCB →	+0.690	+3.125	<.001	.008	3	1
LARGE_INTESTINE	SERAC1 →	+0.678	+3.067	.004	.009	3	1
LARGE_INTESTINE	OR2T8 →	+0.150	+3.179	<.001	.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.013	+2.518	.009	.006	3	1
LARGE_INTESTINE	NEXMIF →	+0.206	+2.518	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

SH3GL2 by TBC1D12 expression — LARGE_INTESTINE

Explore this box plot interactively →