TBC1D10C

Across TCGA pan-cancer cohorts, TBC1D10C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TBC1D10C data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TBC1D10C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TBC1D10C expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where TBC1D10C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
PDAC	DFS	Quartile	All	0.321	0.674	.022	5	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.765	.033	3	view →
CCRCC	DFS	Tertile	II,III,IV	0.885	0.582	.014	3	view →
GBM	DFS	Median	All	0.256	0.436	.049	2	view →
LSCC	DFS	Tertile	All	0.852	0.406	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TBC1D10C–HNSC (OS)

Open the HNSC breakdown →