TBC1D10A

Across TCGA pan-cancer cohorts, TBC1D10A Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TBC1D10A data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TBC1D10A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TBC1D10A expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UVM, COAD, and KIRC are the cancer types where TBC1D10A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.218	0.718	.006	24	view →
COAD	OS	Median	III,IV	0.056	0.783	<.001	24	view →
KIRC	OS	Median	All	0.138	0.655	.019	12	view →
OV	DFS	Median	III,IV	0.140	0.532	.002	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
SKCM	DFS	Median	III,IV	0.163	0.604	.001	5	view →
HNSC	DFS	Median	IV	1.000	0.301	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TBC1D10A–UVM (OS)

Open the UVM breakdown →