TBC1D10A

Across TCGA pan-cancer cohorts, TBC1D10A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TBC1D10A data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TBC1D10A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TBC1D10A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where TBC1D10A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.747	0.553	.011	19	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	4	view →
UCEC	DFS	Median	II,III,IV	0.862	0.553	.029	4	view →
GBM	DFS	Median	All	0.270	0.446	.041	3	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TBC1D10A–HNSC (DFS)

Open the HNSC breakdown →