TBC1D10A

Across TCGA pan-cancer cohorts, TBC1D10A mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TBC1D10A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TBC1D10A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TBC1D10A is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and COAD are the cancer types where TBC1D10A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D10A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.663	<.001	11	view →
LUAD	Male	All	−0.167	<.001	6	view →
COAD	All	III,IV	−0.291	.014	4	view →
LSCC	Male	III,IV	+0.226	.016	3	view →
PDAC	All	IV	+0.150	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TBC1D10A–CCRCC

Open the CCRCC breakdown →