TBC1D10A

Across TCGA patient cohorts, TBC1D10A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D10A-associated genes across cancer lineages are Cyclin-E2, Acetyl-a-Tubulin-Lys40, and JNK_pT183_Y185. Each is linked with TBC1D10A in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D10A-to-partner and partner-to-TBC1D10A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by TBC1D10A-low versus TBC1D10A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D10A→partner) and Y-score (partner→TBC1D10A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.180	+2.817	.042	.036	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.558	+3.321	.036	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.267	-3.308	.002	.010	3	1
UCEC	mTOR_pS2448 →	-0.171	-2.980	.028	.036	3	1
UCEC	Notch1 →	+0.257	+3.321	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.692	+3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Cyclin-E2 by TBC1D10A expression — UCEC

Explore this box plot interactively →