TBC1D1

Across TCGA patient cohorts, TBC1D1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PKC-delta_pS664, and eEF2. Each is linked with TBC1D1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D1-to-partner and partner-to-TBC1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by TBC1D1-low versus TBC1D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D1→partner) and Y-score (partner→TBC1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.444	-1.986	.005	.003	3	3
SKCM	PKC-delta_pS664 →	-0.130	-2.459	.047	.018	3	3
UCEC	eEF2 →	+0.264	+1.874	.036	.049	3	2
UCEC	MEK1 →	+0.495	+2.392	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.445	+3.916	<.001	<.001	3	2
UCEC	p90 RSK_pT359_S363 →	-0.146	-2.000	.041	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

p38-MAPK_pT180_Y182 by TBC1D1 expression — UCEC

Explore this box plot interactively →