TBC1D1

Across TCGA cell cohorts, TBC1D1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,144 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TBC1D1-associated GO terms across cancer lineages are Establishment of spindle orientation, Regulation of sister chromatid segregation, and Spindle localization. Each is linked with TBC1D1 in more than 13 cancer types. Because this analysis shows association rather than direction, both TBC1D1-to-partner and partner-to-TBC1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of spindle orientation grouped by TBC1D1-low versus TBC1D1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D1→partner) and Y-score (partner→TBC1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Establishment of spindle orientation →	+0.137	+1.586	<.001	.006	3	14
BREAST	Regulation of sister chromatid segregation →	+0.128	+2.093	<.001	<.001	3	13
BONE	Spindle localization →	+0.123	+1.750	<.001	<.001	3	12
BONE	Establishment of mitotic spindle localization →	+0.150	+1.847	<.001	.001	3	12
SOFT_TISSUE	Positive regulation of chromosome separation →	+0.129	+1.365	<.001	<.001	3	11
BONE	Establishment of spindle localization →	+0.119	+1.639	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,144 associations by consensus.

Establishment of spindle orientation by TBC1D1 expression — BONE

Explore this box plot interactively →