TAZ

Across TCGA patient cohorts, TAZ mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAZ-associated genes across cancer lineages are Shc_pY317, EGFR_pY1068, and ERK2. Each is linked with TAZ in more than 1 cancer types. Because this analysis shows association rather than direction, both TAZ-to-partner and partner-to-TAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by TAZ-low versus TAZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAZ→partner) and Y-score (partner→TAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.211	-3.584	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.283	-3.584	.005	.002	3	1
UCEC	ERK2 →	+0.238	+3.087	.002	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.185	-1.874	.006	.049	3	1
UCEC	JNK2 →	+0.235	+1.906	.003	.016	3	1
UCEC	Ku80 →	+0.188	+1.498	.047	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Shc_pY317 by TAZ expression — UCEC

Explore this box plot interactively →