TATDN2

Across TCGA patient cohorts, TATDN2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TATDN2-associated genes across cancer lineages are p90 RSK, 4E-BP1, and ERK2. Each is linked with TATDN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TATDN2-to-partner and partner-to-TATDN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by TATDN2-low versus TATDN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TATDN2→partner) and Y-score (partner→TATDN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.138	+1.495	.038	.034	3	2
UCEC	4E-BP1 →	+0.315	+3.584	<.001	.002	3	2
UCEC	ERK2 →	+0.148	+1.440	.027	.024	3	1
UCEC	ACC1 →	+0.250	+1.598	.047	.040	3	1
UCEC	JNK2 →	+0.157	+1.594	.022	.021	3	1
UCEC	MEK1 →	+0.489	+2.938	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p90 RSK by TATDN2 expression — UCEC

Explore this box plot interactively →