TAS2R9

Across TCGA pan-cancer cohorts, TAS2R9 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TAS2R9 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TAS2R9 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TAS2R9 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and STAD are the cancer types where TAS2R9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.628	.021	14	view →
HNSC	DFS	Median	III,IV	0.163	0.680	.019	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
COAD	OS	Median	II,III,IV	0.111	0.853	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LGG	DFS	Median	All	0.192	0.728	.007	3	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →
SKCM	OS	Median	All	0.615	0.795	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TAS2R9–UCEC (DFS)

Open the UCEC breakdown →