TAS2R5

Across TCGA pan-cancer cohorts, TAS2R5 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TAS2R5 data layer compared with 2 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TAS2R5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TAS2R5 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

CESC, KIRC, and UCS are the cancer types where TAS2R5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.654	0.827	<.001	114	view →
KIRC	DFS	Median	II,III,IV	0.396	0.650	.002	53	view →
UCS	OS	Quartile	II,III,IV	0.806	0.254	.004	50	view →
HNSC	OS	Median	III,IV	0.480	0.241	.001	43	view →
BRCA	OS	Quartile	All	0.982	0.950	.005	35	view →
LUAD	DFS	Median	All	0.764	0.848	.005	30	view →
UCEC	OS	Quartile	All	0.605	0.875	.012	28	view →
PAAD	DFS	Tertile	II,III,IV	0.541	0.299	.006	28	view →
THCA	OS	Quartile	III,IV	0.901	1.000	.007	18	view →
KIRP	DFS	Median	III,IV	0.247	0.567	.005	18	view →
MESO	DFS	Median	All	0.286	0.438	.015	15	view →
STAD	DFS	Median	IV	0.206	0.614	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TAS2R5–CESC (DFS)

Open the CESC breakdown →