TAS2R43

Across TCGA patient cohorts, TAS2R43 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R43-associated genes across cancer lineages are FABP12, FABP5P10, and NAP1L4P2. Each is linked with TAS2R43 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R43-to-partner and partner-to-TAS2R43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FABP12 grouped by TAS2R43-low versus TAS2R43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R43→partner) and Y-score (partner→TAS2R43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FABP12 →	+0.330	+4.258	<.001	.003	3	1
UCEC	FABP5P10 →	+0.587	+4.148	<.001	.004	3	1
UCEC	NAP1L4P2 →	+0.124	+3.903	<.001	.006	3	1
UCEC	RPS24P1 →	+0.334	+4.943	<.001	<.001	3	1
UCEC	RPL34P8 →	+0.482	+4.239	<.001	.003	3	1
UCEC	SNORD121A →	+0.994	+4.258	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FABP12 by TAS2R43 expression — UCEC

Explore this box plot interactively →