Across TCGA pan-cancer cohorts, TAS2R42 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TAS2R42 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TAS2R42 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TAS2R42 expression acts as an unfavorable survival marker.

LUAD and UCEC are the cancer types where TAS2R42 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.223	0.677	.006	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TAS2R42 tumor-vs-normal RNA expression · all TAS2R42 data types