TAS2R42

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TAS2R42 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R42-associated genes across cancer lineages are STAT3_pY705, Caspase-7-cleavedD198, and ACC1. Each is linked with TAS2R42 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R42-to-partner and partner-to-TAS2R42 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R42→partner) and Y-score (partner→TAS2R42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSTAT3_pY705 →-0.469-3.000.001.03731
UCECCaspase-7-cleavedD198 →+0.923+2.827.007.03531
UCECACC1 →+0.453+3.000.031.03721
UCECmTOR_pS2448 →-0.176-3.000.041.03721
UCECShc_pY317 →-0.190-3.000.030.03721
UCECPCNA →+0.248+3.000.047.03711
Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration