Across TCGA patient cohorts, TAS2R41 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R41-associated genes across cancer lineages are p90 RSK_pT359_S363, Bim, and A-Raf_pS299. Each is linked with TAS2R41 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R41-to-partner and partner-to-TAS2R41 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R41→partner) and Y-score (partner→TAS2R41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p90 RSK_pT359_S363 →	-0.184	-3.000	.035	.036	2	2
LUAD	Bim →	+0.515	+3.000	<.001	.036	3	1
UCEC	A-Raf_pS299 →	-0.148	-3.169	.023	.020	3	1
UCEC	Paxillin →	+0.332	+3.169	.019	.020	3	1
UCEC	BRD4 →	+0.478	+2.814	.003	.036	3	1
UCEC	Dvl3 →	+0.317	+3.169	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

TAS2R41 survival (RNA) · tumor vs normal (RNA) · all TAS2R41 data types