TAS2R4

Across TCGA patient cohorts, TAS2R4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R4-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and XBP1. Each is linked with TAS2R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R4-to-partner and partner-to-TAS2R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TAS2R4-low versus TAS2R4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R4→partner) and Y-score (partner→TAS2R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.222	-3.000	.012	.036	3	1
UCEC	Notch1 →	+0.208	+2.817	.004	.036	3	1
UCEC	XBP1 →	-0.227	-3.000	.002	.036	3	1
UCEC	ATM →	-0.503	-3.000	.034	.036	3	1
UCEC	BRD4 →	+0.366	+2.177	.009	.035	3	1
UCEC	Caspase-8 →	-0.326	-2.973	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by TAS2R4 expression — UCEC

Explore this box plot interactively →