TAS2R39

Across TCGA patient cohorts, TAS2R39 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R39-associated genes across cancer lineages are p27_pT198, ERK2, and mTOR_pS2448. Each is linked with TAS2R39 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R39-to-partner and partner-to-TAS2R39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by TAS2R39-low versus TAS2R39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R39→partner) and Y-score (partner→TAS2R39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.130	+2.000	.007	.032	3	2
UCEC	ERK2 →	+0.203	+2.000	.019	.032	3	1
UCEC	mTOR_pS2448 →	-0.145	-3.156	.031	.018	3	1
UCEC	mTOR →	-0.228	-2.999	.001	.035	3	1
UCEC	Myosin-IIa →	+0.175	+2.818	.042	.035	3	1
UCEC	Notch1 →	+0.187	+3.179	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

p27_pT198 by TAS2R39 expression — UCEC

Explore this box plot interactively →