TAS2R38

Across TCGA patient cohorts, TAS2R38 mutation is significantly associated with the RNA expression of many other genes, with 3,237 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TAS2R38-associated genes across cancer lineages are PHF5A, TRMU, and DHODH. Each is linked with TAS2R38 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R38-to-partner and partner-to-TAS2R38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by TAS2R38-low versus TAS2R38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R38→partner) and Y-score (partner→TAS2R38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.395	+2.000	.003	.003	3	2
UCEC	TRMU →	+0.378	+2.839	<.001	.001	3	2
UCEC	DHODH →	+0.280	+1.673	.008	.007	3	2
UCEC	VAC14 →	+0.441	+2.424	<.001	<.001	3	2
UCEC	CMC2 →	+0.361	+2.235	.001	.001	3	2
UCEC	VPS18 →	+0.431	+3.823	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,237 associations by consensus.

PHF5A by TAS2R38 expression — UCEC

Explore this box plot interactively →