TAS2R38

Across TCGA patient cohorts, TAS2R38 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R38-associated genes across cancer lineages are MEK1, Caspase-8, and 4E-BP1. Each is linked with TAS2R38 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R38-to-partner and partner-to-TAS2R38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TAS2R38-low versus TAS2R38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R38→partner) and Y-score (partner→TAS2R38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.330	+2.459	.016	.018	3	2
UCEC	Caspase-8 →	-0.251	-2.673	.007	.005	3	2
UCEC	4E-BP1 →	+0.321	+3.614	.001	.001	3	2
SKCM	C-Raf →	+0.147	+1.807	.003	.024	3	2
UCEC	Rab25 →	-0.299	-1.700	.016	.042	3	2
UCEC	Cyclin-B1 →	+0.496	+1.765	.018	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MEK1 by TAS2R38 expression — UCEC

Explore this box plot interactively →