TAS2R3

Across TCGA patient cohorts, TAS2R3 mutation is significantly associated with the RNA expression of many other genes, with 804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R3-associated genes across cancer lineages are SLC25A33, PPP2R2D, and SNRPCP17. Each is linked with TAS2R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R3-to-partner and partner-to-TAS2R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A33 grouped by TAS2R3-low versus TAS2R3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R3→partner) and Y-score (partner→TAS2R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC25A33 →	+0.738	+2.593	<.001	.006	3	2
UCEC	PPP2R2D →	+0.390	+3.625	<.001	.001	3	2
BRCA	SNRPCP17 →	+0.176	+4.995	.003	.009	3	2
UCEC	ALKBH1 →	+0.411	+2.850	.005	.001	3	2
UCEC	PRORP →	+0.413	+3.210	<.001	.009	3	2
UCEC	SRMS →	+1.000	+2.807	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 804 associations by consensus.

SLC25A33 by TAS2R3 expression — UCEC

Explore this box plot interactively →