Across TCGA pan-cancer cohorts, TAS2R2P RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TAS2R2P data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher TAS2R2P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TAS2R2P expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

LIHC, COAD, and ACC are the cancer types where TAS2R2P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.429	0.587	<.001	82	view →
COAD	OS	Quartile	II,III,IV	0.374	0.722	.002	70	view →
ACC	DFS	Median	All	0.315	0.819	<.001	65	view →
MESO	OS	Quartile	All	0.464	0.200	.007	43	view →
LGG	OS	Tertile	All	0.629	0.831	<.001	42	view →
READ	DFS	Tertile	IV	0.296	0.825	<.001	42	view →
STAD	DFS	Median	All	0.586	0.718	.001	39	view →
UCEC	DFS	Quartile	All	0.792	0.873	.023	26	view →
HNSC	DFS	Quartile	All	0.197	0.388	.008	24	view →
UVM	DFS	Quartile	All	0.532	0.800	.002	22	view →
LUAD	DFS	Tertile	All	0.737	0.894	.006	22	view →
THCA	DFS	Tertile	All	0.747	0.914	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

Exploration

Same gene, other analysis: TAS2R2P tumor-vs-normal RNA expression · all TAS2R2P data types