TAS2R20

Across TCGA patient cohorts, TAS2R20 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R20-associated genes across cancer lineages are Ku80, MEK1, and ASNS. Each is linked with TAS2R20 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R20-to-partner and partner-to-TAS2R20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TAS2R20-low versus TAS2R20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R20→partner) and Y-score (partner→TAS2R20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.282	+3.013	.039	.019	3	1
UCEC	MEK1 →	+0.574	+3.000	.006	.036	3	1
UCEC	ASNS →	+0.585	+3.000	.005	.037	3	1
UCEC	p62 Lck ligand →	+0.663	+2.817	<.001	.036	2	1
UCEC	PDCD4 →	-0.599	-3.000	.027	.037	2	1
UCEC	Rad50 →	-0.377	-3.000	.007	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Ku80 by TAS2R20 expression — UCEC

Explore this box plot interactively →