TAS2R20

Across TCGA cell cohorts, TAS2R20 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TAS2R20-associated genes across cancer lineages are TFDP3, LBHD2, and NEXMIF. Each is linked with TAS2R20 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R20-to-partner and partner-to-TAS2R20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by TAS2R20-low versus TAS2R20-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R20→partner) and Y-score (partner→TAS2R20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	LBHD2 →	+0.094	+3.688	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.283	+3.196	<.001	.007	3	1
OVARY	BMP15 →	+0.123	+5.807	<.001	.001	3	1
OVARY	PDHA2 →	+0.006	+5.807	<.001	.001	3	1
OVARY	FTMT →	+0.036	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TFDP3 by TAS2R20 expression — LARGE_INTESTINE

Explore this box plot interactively →