Across TCGA cell cohorts, TAS2R19 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TAS2R19-associated genes across cancer lineages are KRTAP10-1, AVP, and SIGLEC8. Each is linked with TAS2R19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R19-to-partner and partner-to-TAS2R19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R19→partner) and Y-score (partner→TAS2R19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRTAP10-1 →	+0.019	+5.169	<.001	.005	3	2
LARGE_INTESTINE	AVP →	+0.045	+3.632	<.001	.003	3	1
LARGE_INTESTINE	SIGLEC8 →	+0.012	+3.345	<.001	.007	3	1
LARGE_INTESTINE	CYP7A1 →	+0.036	+3.994	<.001	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.020	+3.614	<.001	.006	3	1
BREAST	OOSP2 →	+0.023	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

TAS2R19 survival (RNA) · tumor vs normal (RNA) · all TAS2R19 data types