TAS2R16

Across TCGA cell cohorts, TAS2R16 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS2R16-associated genes across cancer lineages are FHL5, ODF1, and GABRA6. Each is linked with TAS2R16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R16-to-partner and partner-to-TAS2R16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FHL5 grouped by TAS2R16-low versus TAS2R16-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R16→partner) and Y-score (partner→TAS2R16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FHL5 →	+0.162	+4.415	<.001	.007	3	1
SKIN	ODF1 →	+0.020	+5.022	<.001	.002	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.076	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.027	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	SYCP1 →	+0.088	+3.719	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FHL5 by TAS2R16 expression — SKIN

Explore this box plot interactively →