Across TCGA patient cohorts, TAS2R14 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R14-associated genes across cancer lineages are Notch1, Paxillin, and JNK2. Each is linked with TAS2R14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R14-to-partner and partner-to-TAS2R14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R14→partner) and Y-score (partner→TAS2R14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.232	+3.179	<.001	.010	3	2
UCEC	Paxillin →	+0.300	+3.009	.016	.019	3	2
UCEC	JNK2 →	+0.316	+3.179	<.001	.010	3	1
UCEC	Ku80 →	+0.252	+3.598	.027	.001	3	1
UCEC	MEK1 →	+0.488	+3.321	.005	.010	3	1
UCEC	mTOR_pS2448 →	-0.202	-3.156	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

TAS2R14 survival (RNA) · tumor vs normal (RNA) · all TAS2R14 data types