TAS2R10

Across TCGA patient cohorts, TAS2R10 mutation is significantly associated with the RNA expression of many other genes, with 2,354 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R10-associated genes across cancer lineages are NTAN1, LSM3, and TMEM126A. Each is linked with TAS2R10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R10-to-partner and partner-to-TAS2R10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTAN1 grouped by TAS2R10-low versus TAS2R10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R10→partner) and Y-score (partner→TAS2R10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NTAN1 →	+0.509	+2.375	<.001	<.001	3	2
UCEC	LSM3 →	+0.552	+3.119	<.001	<.001	3	2
UCEC	TMEM126A →	+0.397	+2.321	<.001	.001	3	2
UCEC	RGMB →	+0.436	+2.931	.003	<.001	3	2
UCEC	RASSF1 →	+0.397	+3.365	<.001	.004	3	2
UCEC	TOLLIP →	+0.424	+2.849	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,354 associations by consensus.

NTAN1 by TAS2R10 expression — UCEC

Explore this box plot interactively →